Read the following passage and complete the tasks.
MOUNT EVEREST AND HILLARY
Mount Everest, also known as Sagarmartha (Goddess of the Sky), is 8,348 metres tall, the highest mountain on earth above sea level. Formed about 60 million years ago and lying between Tibet and Nepal, Mount Everest appeals to climbers of every level, from novice to experienced climber. Each mountaineer pays a considerable amount of money to an experienced guide to help them achieve a successful climb. Everest was given its official English name in 1865 by the Royal Geographic Society upon recommendation of Andrew Waugh, the British Surveyor General of India at the time.
When Everest was officially announced as the world’s highest mountain in 1852, it won interest from people all over the world, and the idea of climbing all (lie way to the summit was viewed as the ultimate feat. Nobody was able to climb Everest until 1920 when Tibet first opened its borders to outsiders, and between 1920 and 1952, seven major expeditions failed to reach the tip of Mount Everest, In fact, the mountain has a history of adversity and failure. With advances in climbing equipment in the last ten years or so, and more experienced guides, the fatality rates have dropped from 37% in 1990 to 4% in 2004. Nonetheless, the deadliest year in Mount Everest’s history was 1996, when 19 people died near the summit.
In 1924, Mount Everest claimed the lives of its first two climbers. George Mallory and Andrew Irvine were two British climbers, attempting to reach the summit. The men were last seen heading for the top of the mountain until clouds surrounded Everest and they disappeared. Mallory’s body was not seen again until 75 years on, in May of 1999, and Irvine’s body is yet to be found. There is still no evidence as to whether these two men made it to the top or not, although disputes rages on, Those that believe the pair were the first; to climb Everest point to two specific points, firstly, Mallory’s daughter has always said that Mallory carried a photograph of his wife on his person with the intention of leaving it on the summit when he reached it. This photo was not found on the body when it was discovered. Secondly, Mallory’s snow’ goggles were in his pocket when the body was found, indicating that he died at night. This implies that he and Irvine had made a push for the summit and were descending very late in the day. Given their known departure time and movements, had they not made the summit, it is unlikely that they would have still been out by nightfall.
The first time the actual peak of this monstrous mountain was reached was in 1953, in a combined effort by Sir Edmund Hillary and Tenzing Norgay. On the 29th of May that year, the duo conquered this epic mountain, standing at the highest point in the world for a brief 15 minutes. After a brief but fruitless search for evidence of the 1924 Mallory expedition, they buried a cross and some candy in the snow, taking a few photographs of the historic event. As Norgay had never operated a camera, there are no photographs of Hillary on top of the mountain, just shots of Norgay, and some additional photos looking down the mountain, ensuring evidence of their conquest and that the ascent was not faked.
When the news reached London on June 2nd, Sir Edmund Hillary was knighted in the Order of the British Empire and Norgay (a subject of the King of Nepal) was granted the George Medal by the UK, Sir Hillary turned to Antarctic exploration and led the New Zealand section of the Trans-Antarctic expedition from 1955 to 1958. In 1958, he took part in a mechanised expedition to the South Pole. Hillary continued to organise further mountain-climbing expeditions but, as the years passed, he became more and more concerned with the welfare of the Nepalese people. In the 1960s, he returned to Nepal, to aid in the development of the society, building clinics, hospitals and schools. After conquering Everest, Sir Edmund Hillary devoted most of his life to helping the Sherpa people of Nepal through the Himalayan Trust.
In January 2007, Sir Edmund Hillary went to Antarctica to commemorate the 50th anniversary of the founding of Scott Base. He flew to the station on 18 January 2007 with a delegation including the Prime Minister. On the 22nd of April 2007, while on a trip to Kathmandu, he was reported to have suffered a fall. There was no comment on the nature of his illness and lie did not immediately seek treatment. He was hospitalized after returning to New Zealand. Sadly, Sir Edmund Hillary died of a heart attack on the morning of January the 11th 2008. Hillary’s life was marked by wonderful achievements, his giving nature, grand discovery, and excitement. But he was a humble man who did not admit to being the first man to reach the summit of Everest until long after 1386, well after the death of his climbing companion Tenzing Norgay.
The latest record for climbing Mount Everest was set on the 30th of May in 2005 by Nepalese Mona Mulepati and PemDorje Sherpa, who were the first couple to get married on top of Mount Everest.
Answer the questions below using NO MORE THAN THREE WORDS AND/OR A NUMBER from the passage for each answer.
Who suggested that the name Everest be used to refer to the mountain?
Which country prevented explorers from climbing Everest until 1920?
What has not yet been recovered?
What was not found on Mallory’s body that indicates he may have reached the summit?
Who was photographed at the top of the mountain?
What was the name of Hillary’s charitable organization?
Do the following statements agree with the information given in the reading passage?
| TRUE | if the statement agrees with the information |
| FALSE | if the statement contradicts the information |
| NOT GIVEN | if there is no information on this |
Mortality rates on Everest have consistently declined since 1990.
Hillary found evidence of the Mallory expedition.
Photographs were taken from the summit as proof of the Hillary/ Norgay climb.
Both Hillary and Norgay received recognition of their achievement from Britain.
Hillary was the first person to reach the South Pole by mechanised transport.
Hillary’s death was attributed to an accident that occurred in Kathmandu.
Read the following passage and complete the tasks.
SLEEP
A. Like many things about your body, scientists and medical professionals still have a lot to learn about the process of sleep. One earlier misconception that has now been revised is that the body completely slows down during sleep; it is now dear that the body’s major organs and regulatory systems continue to work actively – the lungs, heart and stomach for example. Another important part of the body also operates at night – the glands and lymph nodes, which strengthen the immune system. This is commonly why the body’s natural immunity is weakened with insufficient sleep.
B. In some cases, certain systems actually become more active while we sleep. Hormones required for muscle development and growth, for instance, as well as the growth of new nerve cells. In the brain, activity of the pathways needed for learning and memory is increased.
C. Another common myth about sleep is that the body requires less sleep the older we get. Whilst it is true that babies need 16 hours compared to 9 hours and 8 hours respectively for teenagers and adults, this does not mean that older people need less sleep. However, what is true if that for a number of different factors, they often get less sleep or find their sleep less refreshing. This is because as people age, they spend less time in the deep, restful stages of sleep and are more easily awakened. Older people are also more likely to have medical conditions that affect their sleep, such as insomnia, sleep apnoea and heart problems.
D. Getting a good sleep is not just a matter of your head hitting the pillow at night and waking up in the morning. Your sleep goes in cycles throughout the night, moving back and forth between deep restorative sleep and more alert stages with dreaming. As the night progresses, you spend more time in a lighter dream sleep.
E. Sleep patterns can be broken down into two separate and distinct stages – REM and NREM sleep, REM (Rapid Eye Movement) sleep is when you dream. You usually have 3 to 5 periods of REM sleep each night, lasting from 5 minutes to over an hour, during which time your body’s activities increase. Breathing becomes fast, shallow and uneven, with an increase in brain activity, heartbeat and blood pressure. Although your major muscles generally don’t move, fingers and toes may twitch and body temperature changes and you may sweat or shiver.
F. Research has concluded that this sleep is most important for your brain. It is when it is most active, processing emotions and memories and relieving stress. The areas used for learning and developing more skills are activated. In fact, the brain waves measured during REM sleep are similar to those measured when awake.
G. NREM (Noil-Rapid Eye Movement) sleep is dreamless sleep. NREM sleep consists of four stages of deeper and deeper sleep. As you move through the stages, you become more relaxed, less aware of what is happening around you and more difficult to wake. Your body’s activity will also decrease as you move through the NREM stages, acting in the opposite manner to REM sleep. Stage 1 of NREM sleep is when you are falling to sleep. This period generally lasts between 5 and 10 minutes, during which time you can be woken easily. During stage 2, you are in a light sleep- the in-between stage before your fall into a deep sleep. It lasts about 20 minutes. In stage 3, deep sleep begins, paving the way for stage 4, in which you are difficult to awake and unaware of anything around you. This is when sleep walking and talking can occur. This is the most important stage for your body. Your brain has slowed right down and is recovering. Blood flow is redirected from your brain to your large muscles allowing them to mend any damage from your day at work. People woken quickly from stage 4 sleep often feel a sense of disorientation, which is why it is helpful to use an alarm clock with an ascending ring.
H. About an hour and a half into your sleep cycle you will go from deep Stage 4 sleep back into light Stage 2 sleep, then into REM sleep, before the cycle begins again. About 75% of your sleep is NREM sleep. If you sleep for eight hours, about six of them will be NREM sleep. As the night progresses, you spend more time in dream sleep and lighter sleep.
I. When you constantly get less sleep (even 1 hour less) than you need each night, it is called sleep debt. You may pay for it in daytime drowsiness, trouble concentrating, moodiness, lower productivity and increased risk of falls and accidents. Although a daytime nap cannot replace a good night’s sleep, it can help make up for some of the harm done as a result of sleep debt. But avoid taking a nap after 3 pm as late naps may stop you getting to sleep at night. And avoid napping for longer than 30 minutes as longer naps will make it harder to wake up and get back into the swing of things.
Do the following statements agree with the information, given in the reading passage?
| TRUE | if the statement agrees with the information |
| FALSE | if the statement contradicts the information |
| NOT GIVEN | If there is no information on this |
It was previously believed that biological processes slowed during sleep.
Teenagers lose less sleep than adults when they have a medical condition.
During the night, our sleep becomes increasingly deep.
Lack of sleep can cause heart problems and other medical conditions.
Complete the sentences below using NO MORE THAN THREE WORDS AND/OR A NUMBER from the passage for each answer.
REM sleep can help reduce
During REM sleep, are similar to those recorded whilst awake.
During Stage 1 NREM sleep, you can be with little effort.
Suddenly being woken from deep sleep can cause .
REM sleep _____
Which paragraph contains the following information?
Differences in sleep patterns between generations.
Brain activity is limited as resources are diverted.
Repetition of the cycle.
Dangers of accumulated lack of sleep.
Increased activity during sleep.
Read the following passage and complete the tasks.
CLINICAL TRIALS
A. The benefits of vitamins to our well-being are now familiar to most; however, when the link between diets lacking in citrus fruits and the development of the affliction ‘scurvy’ in sailors was first discovered by James Lind in 1747, the concept of vitamins was yet to be discovered. Scurvy, which causes softening of the gums, oral bleeding and, in extreme cases, tooth loss, is now known to present as a result of lack of Vitamin C in the diet. Additional symptoms include depression, liver spots on the skin – particularly arms and legs – loss of colour in the face and partial immobility; high incidence of the ailment aboard ships took an enormous toll on the crew’s ability to complete essential tasks while at sea.
B. Suggestions that citrus fruit may lower the incidence or indeed prevent scurvy had been made as early as 1600. It was Lind, however, who would conduct the first clinical trial by studying the effect within scientific experimental parameters. However, while the correlation between consuming citrus fruit and avoidance of scurvy was established, the preventative properties were attributed to the presence of acids in the fruit and not what would later be identified as vitamin content.
C. Lind’s subjects for his trial consisted of twelve sailors already exhibiting symptoms of scurvy. These individuals were split into six groups; each pair common diet. Pair 1 were rationed a daily quart of cider, pair 2 elixir of vitriol, pair 3 a given quantity of vinegar, pair 4 seawater, pair 5 oranges and a lemon and pair 6 barley water. Despite the trial having to be aborted after day five, when supplies of fruit were depleted, the findings of the interventional study showed that only the control group who were given fruit supplements showed any significant improvement in their condition (one had, in fact, recovered to the extent that he was fit enough to return to work). The immediate impact on sailors’ health and incidence of scurvy on board ship was, however, limited as Lind and other physicians remained convinced that the curative effect was acid based. Therefore, while consumption of citrus fruit was recommended, it was often replaced by cheaper acid supplements. The preventative Qualities of citrus fruit against scurvy were not truly recognised until 1800, though throughout the latter part of the 1700s, lemon juice was increasingly administered as a cure for sailors already afflicted.
D. Nowadays, the implementation of findings discovered in clinical trials into mainstream medicine remains an arduous and lengthy process and the clinical trials themselves represent only a small stage of the process of developing a new drug from research stage to launch in the marketplace. On average, for every thousand drugs conceived, only one of the thousand actually makes it to the stage of clinical trial, other projects being abandoned for a variety of reasons. Stages which need to be fulfilled prior to clinical trial – where the treatment is actually tested on human subjects -include discovery, purification, characterisation and laboratory testing.
E. A new pharmaceutical for treatment of a disease such as cancer typically takes a period of 6 years or more before reaching the stage of clinical trial. Since legislation requires subjects participating in such trials to be monitored for a considerable period of time so that side-effects and benefits can be assessed correctly, a further eight years typically passes between the stage of a drug entering clinical trial and being approved for general use. One of the greatest barriers to clinical trial procedures is availability of subjects willing to participate. Criteria for selection is rigorous and trials where subjects are required to be suffering from the disease in question, experience tremendous recruitment difficulties as individuals already vulnerable due to the effects of their condition, are often reluctant to potentially put their health at higher levels of risk.
F. Clinical trials are conducted in line with a strict protocol and the stages of a trial are generally defined by five distinct phases. A drug that is deemed safe and effective enough to reach the end of stage three is most often, at that point, approved for use in mainstream medicine. Phase 0 involves a first-in-human trial (usually conducted using a small population often to fifteen subjects) with the purpose of ascertaining that the drug’s effect is, in fact, the same as predicted in pre-clinical studies. If no concerns are raised, the drug then enters Phase 1 of trial where a modest selection (usually between twenty and eighty subjects) of usually healthy volunteers, is exposed to the drug. However, for HIV and cancer drugs, this stage is conducted using patients suffering from the condition in question. There are two main variations of Phase I testing, these being SAD (single ascending dose) and MAD (multiple ascending dose). The former involves a single administration of a drug at a pre-determined level to one group of subjects, and the second involves administration of a pre-determined sequence of dosages.
G. Phases 0 and 1 are geared towards establishing the safety of a pharmaceutical and once this has been confirmed, drugs pass into Phase II testing where, while safety continues to be monitored, the drug’s effectiveness is also assessed using a larger group of subjects, ranging from twenty up to three hundred. In some trials, Phase II is regarded as involving two sub-stages, in that Phase 11(a) may be concerned with establishing optimum dosage levels and Phase 11(b) to evaluate effectiveness. Phase III is the most expensive, time-consuming and complex stage of the trial process, often involving as many as 3000 patients. At this stage, a new drug’s effectiveness is rigorously tested and compared to that of the best of the existing alternatives already approved and in common use. Where research indicates that a pharmaceutical has passed all requirements of Phases 0, I, II and III, submissions to relevant regulatory and licensing bodies are then made.
H. The final phase of clinical testing, Phase IV, is conducted over a lengthy period of time post-launch for general usage. This stage is, in essence, a safety net which involves continued monitoring of the drug, its properties and side-effects through which any long term adverse reactions, which remained undetected in the pre-launch clinical testing time frame can be discovered. Identification of harmful effects at this stage, on occasion, has led to withdrawal of a drug from the market; for example, as was the case with cerivastin, a cholesterol-lowering drug, which was later found to have an adverse effect on muscle reaction which, on occasion, had fatal consequences.
Complete the sentences below.
Choose NO MORE THAN TWO WORDS from the passage for each answer.
In advanced cases of scurvy suffers may experience along with numerous other symptoms.
Fruit adds were mistakenly heralded as having in incidents of scurvy prior to the identification of vitamins.
Lind’s subjects for the first clinical trial were seamen who were at the time of the condition in question.
All groups in Lind’s experiment were given a along with specific rations which were varied for each control group.
The first clinical trial was conducted for only 5 days because _____.
The impact of findings from the trial were not used to full potential because _____.
One of the greatest hindrances to clinical testing today is ______.
Clinical testing for HIV and cancer drugs differs from usual procedures because _____.
Complete the flowchart
Choose ONE WORD ONLY from the passage for each answer.

| 36. | 39. |
| 37. | 40. |
| 38. |